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Sci. Signal., 21 July 2009
Vol. 2, Issue 80, p. pe42
[DOI: 10.1126/scisignal.280pe42]

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Thwarting Dyskinesia by Targeting mTORC1

Eric Klann*

Center for Neural Science, New York University, New York, NY 10003, USA.

Abstract: In a mouse model of Parkinson’s disease, new evidence shows that L-DOPA, which is used to treat the symptoms of the disease but also causes dyskinesia, results in a persistent activation of the protein kinase mTOR (mammalian target of rapamycin) in a subset of striatal medium spiny neurons. Moreover, blockade of a specific type of mTOR signaling (mTORC1) prevents the development of dyskinesia, but not the antiakinetic benefits produced by L-DOPA. Thus, mTORC1 may be a viable therapeutic target for dyskinesia caused by L-DOPA treatment in patients with Parkinson’s disease.

* Corresponding author. E-mail, eklann{at}cns.nyu.edu

Citation: E. Klann, Thwarting Dyskinesia by Targeting mTORC1. Sci. Signal. 2, pe42 (2009).

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