Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.


Sci. Signal., 28 July 2009
Vol. 2, Issue 81, p. pe45
[DOI: 10.1126/scisignal.281pe45]


Proteomic Revelation: SUMO Changes Partners When the Heat Is On

Karin Flick and Peter Kaiser*

Department of Biological Chemistry, School of Medicine, University of California, Irvine, CA 92697, USA.

Abstract: Dynamic changes in the posttranslational modification of proteins govern most cellular signaling pathways. Work over the past decade has connected many of these processes with the covalent attachment of the small ubiquitin-like modifier (SUMO) protein to target proteins, but a global view of the dynamics of SUMOylation was missing. A system-level proteomics approach has now been used to describe quantitative changes in protein modification with the SUMO-2 paralog during the response to heat shock. The SUMOylation status of more than 700 proteins was monitored in HeLa cells during the induction of hyperthermic stress and the recovery period. A massive redistribution of SUMO-2 was observed that affected many biological pathways that are important for the heat shock response, including cell cycle regulation, transcription, translation, protein folding, and DNA repair. Collectively, these data suggest a wide-ranging role for SUMOylation in the cellular response to hyperthermic stress. The strategies that were developed to provide this global view of SUMOylation should guide future approaches to probing quantitative changes in protein modification.

* Corresponding author. E-mail, pkaiser{at}

Citation: K. Flick, P. Kaiser, Proteomic Revelation: SUMO Changes Partners When the Heat Is On. Sci. Signal. 2, pe45 (2009).

Read the Full Text

The Small Ubiquitin-like Modifier-Deconjugating Enzyme Sentrin-Specific Peptidase 1 Switches IFN Regulatory Factor 8 from a Repressor to an Activator during Macrophage Activation.
T.-H. Chang, S. Xu, P. Tailor, T. Kanno, and K. Ozato (2012)
J. Immunol. 189, 3548-3556
   Abstract »    Full Text »    PDF »
Science Signaling Podcast: 28 July 2009.
M. B. Yaffe and A. M. VanHook (2009)
Science Signaling 2, pc14
   Abstract »    Full Text »

To Advertise     Find Products

Science Signaling. ISSN 1937-9145 (online), 1945-0877 (print). Pre-2008: Science's STKE. ISSN 1525-8882