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Sci. Signal., 28 July 2009
Vol. 2, Issue 81, p. pe47
[DOI: 10.1126/scisignal.281pe47]

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Dynamic Advances in NF-{kappa}B Signaling Analysis

Taeko Kobayashi* and Ryoichiro Kageyama

Institute for Virus Research, Kyoto University, Shogoin-Kawahara, Sakyo-ku; Japan Science and Technology Agency, CREST, Kyoto 606-8507, Japan.

Abstract: Signaling through the transcription factor nuclear factor {kappa}B (NF-{kappa}B) regulates various physiological processes, including immune responses and inflammation. An analysis of NF-{kappa}B dynamics suggests that the oscillation frequency of NF-{kappa}B activation determines which downstream genes are expressed, enabling a single pathway to respond to diverse stimuli in distinct ways.

* Corresponding author. Telephone, 81-75-751-4013; fax, 81-75-751-4807; e-mail, tkobayas{at}virus.kyoto-u.ac.jp.

Citation: T. Kobayashi, R. Kageyama, Dynamic Advances in NF-{kappa}B Signaling Analysis. Sci. Signal. 2, pe47 (2009).

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