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Sci. Signal., 18 August 2009
Vol. 2, Issue 84, p. pe52
[DOI: 10.1126/scisignal.284pe52]


miRNA Regulation Through Ligand Occupancy of a Nuclear Hormone Receptor

Ann E. Rougvie*

University of Minnesota, Department of Genetics, Cell Biology and Development, 6-160 Jackson Hall, 321 Church Street SE, Minneapolis, MN 55455, USA.

Abstract: MicroRNAs (miRNAs) posttranscriptionally regulate gene expression, but the factors that direct transcription of miRNAs are not well characterized. Activation versus repression of key developmental miRNAs in Caenorhabditis elegans is directly mediated by ligand occupancy of a nuclear hormone receptor that acts to couple nutrient availability to developmental programs.

* Corresponding author. E-mail: rougvie{at}

Citation: A. E. Rougvie, miRNA Regulation Through Ligand Occupancy of a Nuclear Hormone Receptor. Sci. Signal. 2, pe52 (2009).

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