Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.
Subscribe

Sci. Signal., 1 September 2009
Vol. 2, Issue 86, p. ra49
[DOI: 10.1126/scisignal.2000338]

RESEARCH ARTICLES

IL-1 Induces IGF-Dependent Epithelial Proliferation in Prostate Development and Reactive Hyperplasia

Travis J. Jerde* and Wade Bushman*

Department of Urology, University of Wisconsin School of Medicine and Public Health, Madison, WI 53792, USA.

Abstract: Chronic inflammation and reactivation of developmental signaling pathways are both hallmarks of adenocarcinomas. However, developmental and inflammatory processes are generally thought of as distinct and are believed to represent separate paths to carcinogenesis. Here, we show that the inflammatory cytokine interleukin-1{alpha} (IL-1{alpha}) plays a critical role in prostate development by activating insulin-like growth factor (IGF) signaling; this process is reiterated during inflammatory reactive hyperplasia to elicit epithelial proliferation. The appearance of developmental signals during hyperplasia supports the hypothesis that reactivation of developmental signaling plays a role in the hyperplasic reaction to inflammation and suggests that there may be a conserved link between inflammatory signaling and canonical developmental pathways.

* To whom correspondence should be addressed. E-mail: jerde{at}urology.wisc.edu (T.J.J.) and bushman{at}urology.wisc.edu (W.B.)

Citation: T. J. Jerde, W. Bushman, IL-1 Induces IGF-Dependent Epithelial Proliferation in Prostate Development and Reactive Hyperplasia. Sci. Signal. 2, ra49 (2009).

Read the Full Text

THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Intracellular Insulin-like Growth Factor-1 Induces Bcl-2 Expression in Airway Epithelial Cells.
H. S. Chand, J. F. Harris, Y. Mebratu, Y. Chen, P. S. Wright, S. H. Randell, and Y. Tesfaigzi (2012)
J. Immunol. 188, 4581-4589
   Abstract »    Full Text »    PDF »

To Advertise     Find Products

Science Signaling. ISSN 1937-9145 (online), 1945-0877 (print). Pre-2008: Science's STKE. ISSN 1525-8882