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Sci. Signal., 8 September 2009
Vol. 2, Issue 87, p. ec298
[DOI: 10.1126/scisignal.287ec298]

EDITORS' CHOICE

DNA Repair Damage, Signal, Maneuver

Guy Riddihough

Science, AAAS, Washington, DC 20005, USA

Cellular processes, such as transcription and DNA repair, require modification and manipulation of chromosomally associated proteins by a diverse set of chromatin remodeling complexes. The mechanisms by which cells regulate chromatin remodeling are not completely understood. During the response elicited by DNA damage, the addition of poly(ADP-ribose) to chromatin is associated with chromatin decondensation, which is thought to promote efficient DNA repair. Ahel et al. have identified a chromatin remodeling enzyme as a DNA damage-response protein, which binds poly(ADP-ribose) and is recruited to sites of DNA damage.

D. Ahel, Z. Horejsí, N. Wiechens, S. E. Polo, E. Garcia-Wilson, I. Ahel, H. Flynn, M. Skehel, S. C. West, S. P. Jackson, T. Owen-Hughes, S. J. Boulton, Poly(ADP-ribose)–dependent regulation of DNA repair by the chromatin remodeling enzyme ALC1. Science 325, 1240–1243 (2009). [Abstract] [Full Text]

Citation: G. Riddihough, Damage, Signal, Maneuver. Sci. Signal. 2, ec298 (2009).


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