Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.
Subscribe

Sci. Signal., 8 September 2009
Vol. 2, Issue 87, p. ec298
[DOI: 10.1126/scisignal.287ec298]

EDITORS' CHOICE

DNA Repair Damage, Signal, Maneuver

Guy Riddihough

Science, AAAS, Washington, DC 20005, USA

Cellular processes, such as transcription and DNA repair, require modification and manipulation of chromosomally associated proteins by a diverse set of chromatin remodeling complexes. The mechanisms by which cells regulate chromatin remodeling are not completely understood. During the response elicited by DNA damage, the addition of poly(ADP-ribose) to chromatin is associated with chromatin decondensation, which is thought to promote efficient DNA repair. Ahel et al. have identified a chromatin remodeling enzyme as a DNA damage-response protein, which binds poly(ADP-ribose) and is recruited to sites of DNA damage.

D. Ahel, Z. Horejsí, N. Wiechens, S. E. Polo, E. Garcia-Wilson, I. Ahel, H. Flynn, M. Skehel, S. C. West, S. P. Jackson, T. Owen-Hughes, S. J. Boulton, Poly(ADP-ribose)–dependent regulation of DNA repair by the chromatin remodeling enzyme ALC1. Science 325, 1240–1243 (2009). [Abstract] [Full Text]

Citation: G. Riddihough, Damage, Signal, Maneuver. Sci. Signal. 2, ec298 (2009).

To Advertise     Find Products

Science Signaling. ISSN 1937-9145 (online), 1945-0877 (print). Pre-2008: Science's STKE. ISSN 1525-8882