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Sci. Signal., 8 September 2009
Vol. 2, Issue 87, p. re6
[DOI: 10.1126/scisignal.287re6]


Oncogenic EGFR Signaling Networks in Glioma

Paul H. Huang1*, Alexander M. Xu2, and Forest M. White2,3

1 Protein Networks Team, Section of Cell and Molecular Biology, Institute of Cancer Research, London SW3 6JB, UK.
2 Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
3 Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.

Abstract: The epidermal growth factor receptor (EGFR) is a primary contributor to glioblastoma (GBM) initiation and progression. Here, we examine how EGFR and key downstream signaling networks contribute to the hallmark characteristics of GBM such as rapid cancer cell proliferation and diffused invasion. Additionally, we discuss current therapeutic options for GBM patients and elaborate on the mechanisms through which EGFR promotes chemoresistance. We conclude by offering a perspective on how the potential of integrative systems biology may be harnessed to develop safe and effective treatment strategies for this disease.

* Corresponding author. E-mail, paul.huang{at}

Citation: P. H. Huang, A. M. Xu, F. M. White, Oncogenic EGFR Signaling Networks in Glioma. Sci. Signal. 2, re6 (2009).

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