Sci. Signal., 15 September 2009
Structural Biology Crystal Clear
L. Bryan Ray
Science, Science Signaling, AAAS, Washington, DC 20005, USA
Guanine nucleotide exchange factors (GEFs) stimulate exchange of guanine diphosphate (GDP) for guanine triphosphate (GTP) and activate small guanosine triphosphatases (GTPases) required for the regulation of many biological processes. Yang et al. provide a detailed picture of the complete catalytic cycle by which a GEF, DOCK9, activates the small GTPase Cdc42. A small region of DOCK9 appears to sense whether GTP or GDP is bound to Cdc42 in a mechanism that is distinct from that observed for other GTPases.
Citation: L. B. Ray, Crystal Clear. Sci. Signal. 2, ec305 (2009).
Science Signaling. ISSN 1937-9145 (online), 1945-0877 (print). Pre-2008: Science's STKE. ISSN 1525-8882