Focus Issue: The Long and Short of Redox Signaling

Nancy R. Gough^1*

¹ Editor of Science Signaling, American Association for the Advancement of Science, 1200 New York Avenue, N.W., Washington, DC 20005, USA.

Abstract: Reduction-oxidation reactions produce reactive species that regulate cellular behavior, predominantly by posttranslationally modifying cysteine residues on target proteins. Research Articles, as well as a Perspective and Review in this issue, provide insight into the pathological potential of reactive oxygen species (ROS), as well as the important physiological signals that the reactive molecules transmit and the biological processes that they regulate.

* Corresponding author. E-mail: ngough{at}aaas.org

The editors suggest the following Related Resources on Science sites:

In Science Signaling

PERSPECTIVES
Microbiology
S-Nitrosylation Signaling in Escherichia coli

Ivan Gusarov and Evgeny Nudler (12 June 2012)
Sci. Signal. 5 (228), pe26. [DOI: 10.1126/scisignal.2003181]
 |  Abstract »  |  Full Text »  |  PDF »

EDITORS' CHOICE
Cell Migration
Sensing H₂O₂ with Lyn

Nancy R. Gough (6 December 2011)
Sci. Signal. 4 (202), ec341. [DOI: 10.1126/scisignal.4202ec341]
 |  Abstract »

EDITORS' CHOICE
Cell Biology
Not All Oxidative Stresses Are the Same

Nancy R. Gough (4 October 2011)
Sci. Signal. 4 (193), ec280. [DOI: 10.1126/scisignal.4193ec280]
 |  Abstract »

EDITORS' CHOICE
Cancer
Regulating ROS for Tumorigenicity

Elizabeth M. Adler (12 July 2011)
Sci. Signal. 4 (181), ec192. [DOI: 10.1126/scisignal.4181ec192]
 |  Abstract »

EDITORS' CHOICE
Cell Biology
Inflammatory Mitochondria

Wei Wong (18 January 2011)
Sci. Signal. 4 (156), ec15. [DOI: 10.1126/scisignal.4156ec15]
 |  Abstract »

EDITORS' CHOICE
Plant Biology
UPBEAT Growth

Wei Wong (23 November 2010)
Sci. Signal. 3 (149), ec354. [DOI: 10.1126/scisignal.3149ec354]
 |  Abstract »

PROTOCOLS
Biochemistry
Targeting the Reversibly Oxidized Protein Tyrosine Phosphatase Superfamily

Benoit Boivin, Ming Yang, and Nicholas K. Tonks (31 August 2010)
Sci. Signal. 3 (137), pl2. [DOI: 10.1126/scisignal.3137pl2]
 |  Abstract »  |  Full Text »  |  PDF »

REVIEWS
Oxidative Stress
Stress-Activated Cap'n'collar Transcription Factors in Aging and Human Disease

Gerasimos P. Sykiotis and Dirk Bohmann (9 March 2010)
Sci. Signal. 3 (112), re3. [DOI: 10.1126/scisignal.3112re3]
 |  Gloss »  |  Abstract »  |  Full Text »  |  PDF »

EDITORS' CHOICE
Redox Signaling
Keeping H₂O₂ Where You Need It

Wei Wong (2 March 2010)
Sci. Signal. 3 (111), ec65. [DOI: 10.1126/scisignal.3111ec65]
 |  Abstract »

EDITORS' CHOICE
Redox Signaling
The Sensitive Side of ROS

Wei Wong (13 October 2009)
Sci. Signal. 2 (92), ec334. [DOI: 10.1126/scisignal.292ec334]
 |  Abstract »

EDITORS' CHOICE
Redox Signaling
Differentiated with ROS

Nancy R. Gough (29 September 2009)
Sci. Signal. 2 (90), ec321. [DOI: 10.1126/scisignal.290ec321]
 |  Abstract »