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Sci. Signal., 20 October 2009
Vol. 2, Issue 93, p. ec342
[DOI: 10.1126/scisignal.293ec342]

EDITORS' CHOICE

Neuroscience Subcortical Network Regulation

Peter Stern

Science, AAAS, Cambridge CB2 1LQ, UK

Subcortical neuromodulatory centers dominate the motivational and emotional state–dependent control of cortical functions. Control of cortical circuits has been thought to involve a slow, diffuse neuromodulation that affects the excitability of large numbers of neurons relatively indiscriminately. Varga et al. describe a form of subcortical control of cortical information processing whereby strong, spatiotemporally precise excitatory input from midbrain serotonergic neurons produces a robust activation of hippocampal interneurons. This effect is mediated by a synaptic release of both serotonin and glutamate and impacts network activity patterns.

V. Varga, A. Losonczy, B. V. Zemelman, Z. Borhegyi, G. Nyiri, A. Domonkos, B. Hangya, N. Holderith, J. C. Magee, T. F. Freund, Fast synaptic subcortical control of hippocampal circuits. Science 326, 449–453 (2009). [Abstract] [Full Text]

Citation: P. Stern, Subcortical Network Regulation. Sci. Signal. 2, ec342 (2009).


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