Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.

Subscribe

Sci. Signal., 27 October 2009
Vol. 2, Issue 94, p. ec349
[DOI: 10.1126/scisignal.294ec349]

EDITORS' CHOICE

Developmental Neurobiology Cdc20-APC in Synapse Formation

L. Bryan Ray

Science, Science Signaling, AAAS, Washington, DC 20005, USA

The E3 ubiquitin ligase Cdc20-anaphase promoting complex (Cdc20-APC) has important roles in the control of the cell division cycle. Yang et al. now show that Cdc20-APC also appears to be required for proper formation of synapses by developing neurons in the rat brain. When Cdc20-APC was depleted from cultured neurons or in the brains of developing rat pups, synapse formation was inhibited. The brain-enriched transcription factor NeuroD2 was shown to be a possible target of Cdc20-APC–stimulated degradation. NeuroD2 may act by promoting synthesis of Complexin II, a protein that regulates synaptic vesicle fusion.

Y. Yang, A. H. Kim, T. Yamada, B. Wu, P. M. Bilimoria, Y. Ikeuchi, N. de la Iglesia, J. Shen, A. Bonni, A Cdc20-APC ubiquitin signaling pathway regulates presynaptic differentiation. Science 326, 575–578 (2009). [Abstract] [Full Text]

Citation: L. B. Ray, Cdc20-APC in Synapse Formation. Sci. Signal. 2, ec349 (2009).


To Advertise     Find Products


Science Signaling. ISSN 1937-9145 (online), 1945-0877 (print). Pre-2008: Science's STKE. ISSN 1525-8882