Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.
Subscribe

Sci. Signal., 3 November 2009
Vol. 2, Issue 95, p. pe69
[DOI: 10.1126/scisignal.295pe69]

PERSPECTIVES

In with the TRP Channels: Intracellular Functions for TRPM1 and TRPM2

Sandip Patel1* and Roberto Docampo2*

1 Department of Cell and Developmental Biology, University College London, London WC1E 6BT, UK.
2 Center for Tropical and Emerging Global Diseases and Department of Cellular Biology, University of Georgia, Athens, GA 30602, USA.

Abstract: Transient receptor potential (TRP) channels are a large family of cation channels, many of which are predominantly localized to the plasma membrane, where they transduce the effects of diverse and often sensory stimuli. Two members of the TRP melastatin subfamily, TRPM1 and TRPM2, are localized in intracellular compartments and are involved in melanin synthesis and oxidative stress–induced cell death, respectively. These findings provide new insight into the location and function of TRP channels.

* Corresponding authors. E-mail, patel.s{at}ucl.ac.uk (S.P.); rdocampo{at}uga.edu (R.D.)

Citation: S. Patel, R. Docampo, In with the TRP Channels: Intracellular Functions for TRPM1 and TRPM2. Sci. Signal. 2, pe69 (2009).

Read the Full Text

THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Cell Death and Autophagy under Oxidative Stress: Roles of Poly(ADP-Ribose) Polymerases and Ca2+.
P. Wyrsch, C. Blenn, J. Bader, and F. R. Althaus (2012)
Mol. Cell. Biol. 32, 3541-3553
   Abstract »    Full Text »    PDF »
Role of TRPML and Two-Pore Channels in Endolysosomal Cation Homeostasis.
C. Grimm, S. Hassan, C. Wahl-Schott, and M. Biel (2012)
J. Pharmacol. Exp. Ther. 342, 236-244
   Abstract »    Full Text »    PDF »
Constitutive Activity of TRPML2 and TRPML3 Channels versus Activation by Low Extracellular Sodium and Small Molecules.
C. Grimm, S. Jors, Z. Guo, A. G. Obukhov, and S. Heller (2012)
J. Biol. Chem. 287, 22701-22708
   Abstract »    Full Text »    PDF »
A Role for Nyctalopin, a Small Leucine-Rich Repeat Protein, in Localizing the TRP Melastatin 1 Channel to Retinal Depolarizing Bipolar Cell Dendrites.
J. N. Pearring, P. Bojang Jr, Y. Shen, C. Koike, T. Furukawa, S. Nawy, and R. G. Gregg (2011)
J. Neurosci. 31, 10060-10066
   Abstract »    Full Text »    PDF »
Planar Patch Clamp Approach to Characterize Ionic Currents from Intact Lysosomes.
M. Schieder, K. Rotzer, A. Bruggemann, M. Biel, and C. Wahl-Schott (2010)
Science Signaling 3, pl3
   Abstract »    Full Text »    PDF »
A Single Residue in a Novel ADP-ribosyl Cyclase Controls Production of the Calcium-mobilizing Messengers Cyclic ADP-ribose and Nicotinic Acid Adenine Dinucleotide Phosphate.
L. Ramakrishnan, H. Muller-Steffner, C. Bosc, V. D. Vacquier, F. Schuber, M.-J. Moutin, L. Dale, and S. Patel (2010)
J. Biol. Chem. 285, 19900-19909
   Abstract »    Full Text »    PDF »

To Advertise     Find Products

Science Signaling. ISSN 1937-9145 (online), 1945-0877 (print). Pre-2008: Science's STKE. ISSN 1525-8882