Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.

Subscribe

Sci. Signal., 10 November 2009
Vol. 2, Issue 96, p. pe74
[DOI: 10.1126/scisignal.296pe74]

PERSPECTIVES

Nutrition-Minded Cell Cycle

Kazuhiro Shiozaki*

Department of Microbiology, University of California, Davis, CA 95616, USA.

Abstract: For decades, the fission yeast Schizosaccharomyces pombe has been used as an excellent model with which to explore how cellular growth is coordinated with the division cycle, a yet-unanswered question in biology. New studies in this organism show that TOR (target of rapamycin) kinase and stress-responsive MAPK (mitogen-activated protein kinase) form a signaling pathway that readjusts the timing of mitotic onset in response to poor nutrient conditions. Nutritional environment appears to be translated into graded activity of the protein kinases that influence the activation of Cdc2, a cyclin-dependent kinase driving cell-cycle progression.

* Corresponding author. E-mail, kshiozaki{at}ucdavis.edu

Citation: K. Shiozaki, Nutrition-Minded Cell Cycle. Sci. Signal. 2, pe74 (2009).

Read the Full Text


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
A conserved cell growth cycle can account for the environmental stress responses of divergent eukaryotes.
N. Slavov, E. M. Airoldi, A. van Oudenaarden, and D. Botstein (2012)
Mol. Biol. Cell 23, 1986-1997
   Abstract »    Full Text »    PDF »

To Advertise     Find Products


Science Signaling. ISSN 1937-9145 (online), 1945-0877 (print). Pre-2008: Science's STKE. ISSN 1525-8882