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Sci. STKE, 11 January 2000
Vol. 2000, Issue 14, p. tw9
[DOI: 10.1126/stke.2000.14.tw9]

EDITORS' CHOICE

G PROTEINS G Protein Orders Growth

Abstract: Heterotrimeric guanine nucleotide-binding proteins (G proteins) couple activation of G protein-coupled receptors on the cell surface to modulation of a large array of diverse biological effects. The subunits of the G proteins interact with effectors to bring about such responses. A member of the G{alpha} subunit family, G{alpha}o, when mutated to remain constantly in an active form (G{alpha}o*), causes transformation of NIH 3T3 cells. Ram et al. explored the signaling pathways that mediate this effect of G{alpha}o. They find that Stat3 (for signal transducer and activator of transcription 3) is activated in cells expressing G{alpha}o* and appears to be necessary for the growth-promoting action of G{alpha}o*. Stats are transcription factors activated by tyrosine phosphorylation in response to cytokine receptors (which are not coupled to G proteins). In this case, however, G{alpha}o seems to stimulate the tyrosine kinase c-Src, which in turn activates Stat3 and contributes to abnormal cellular proliferation.

Ram, P.T., Horvath, C.M., and Iyengar, R. (2000) Stat3-mediated transformation of NIH-3T3 cells by the constitutively active Q205L Go protein. Science 287: 142-144. [Abstract] [Full Text]

Citation: G Protein Orders Growth. Sci. STKE 2000, tw9 (2000).

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