Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.
STEM Talent Event

Site Tools

  • AAAS
  • Subscribe
  • Feedback

Site Search

Search Advanced

Sci. STKE, 18 January 2000
Vol. 2000, Issue 15, p. pe1
[DOI: 10.1126/stke.2000.15.pe1]

PERSPECTIVES

EGF Receptor Transactivation Mediated by the Proteolytic Production of EGF-like Agonists

Graham Carpenter

The author is in the Department of Biochemistry, Vanderbilt University School of Medicine, Nashville, TN 37232–0146, USA. E-mail: graham.carpenter{at}mcmail.vanderbilt.edu

Abstract: The epidermal growth factor (EGF) receptor is activated not only by EGF-like ligands, but also by stimuli that do not directly act on the receptor, including agonists of G protein–coupled receptors and certain environmental stresses such as ionizing radiation. Carpenter discusses two reports that indicate EGF receptor activation by such heterologous stimuli may occur through the action of proteases that release cell surface EGF-like growth factor precursors. This mechanism of EGF receptor transactivation appears to involve the generation of soluble agonists.

Citation: G. Carpenter, EGF Receptor Transactivation Mediated by the Proteolytic Production of EGF-like Agonists. Sci. STKE 2000, pe1 (2000).

Read the Full Text

THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
{beta}-Blockers alprenolol and carvedilol stimulate {beta}-arrestin-mediated EGFR transactivation.
I.-M. Kim, D. G. Tilley, J. Chen, N. C. Salazar, E. J. Whalen, J. D. Violin, and H. A. Rockman (2008)
PNAS 105, 14555-14560
   Abstract »    Full Text »    PDF »
Structure and activity of the axon guidance protein MICAL.
M. Nadella, M. A. Bianchet, S. B. Gabelli, J. Barrila, and L. M. Amzel (2005)
PNAS 102, 16830-16835
   Abstract »    Full Text »    PDF »
Peroxiredoxin III, a Mitochondrion-specific Peroxidase, Regulates Apoptotic Signaling by Mitochondria.
T.-S. Chang, C.-S. Cho, S. Park, S. Yu, S. W. Kang, and S. G. Rhee (2004)
J. Biol. Chem. 279, 41975-41984
   Abstract »    Full Text »    PDF »

ADVERTISEMENT
Click Me!

ADVERTISEMENT
Click Me!

To Advertise     Find Products

Science Signaling. ISSN 1937-9145 (pre-2008: Science's STKE. ISSN 1525-8882)