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Sci. STKE, 8 February 2000
Vol. 2000, Issue 18, p. tw8
[DOI: 10.1126/stke.2000.18.tw8]


Transcriptional Regulation Ras Proteins and I{kappa}B Degradation

The I{kappa}B proteins are inhibitors of the NF-{kappa}B transcription factor, which has major functions in gene regulation in response to inflammatory stimuli of the immune system. In this system, transcription is controlled though regulated proteolysis of the I{kappa}B inhibitory proteins. In screening proteins that interact with I{kappa}B, Fenwick et al. detected a protein they call {kappa}B-Ras1 because of its similarity to the small guanosine triphosphatase Ras. The {kappa}B-Ras1 protein is unusual in that it has mutations similar to those found in oncogenic mutants of Ras. The {kappa}B-Ras1 and I{kappa}B proteins were shown to interact in intact cells. Overexpression of {kappa}B-Ras1 decreased degradation of I{kappa}B proteins in cells and consequently decreased NF-{kappa}B-dependent transcription. The {kappa}B-Ras1 protein appears to associate specifically with complexes of NF-{kappa}B with I{kappa}Bβ, which may explain why I{kappa}Bβ is degraded more slowly than is I{kappa}Bα.

Fenwick, C., Na, S.-Y., Voll, R.E., Zhong, H., Im, S.-Y., Lee, J.W., and Ghosh, S. (2000) A subclass of Ras proteins that regulate the degradation of I{kappa}B. Science 287: 869-873. [Abstract] [Full Text]

Citation: Ras Proteins and I{kappa}B Degradation. Sci. STKE 2000, tw8 (2000).

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