Sci. STKE, 8 February 2000
Transcriptional Regulation Ras Proteins and IB Degradation
The IB proteins are inhibitors of the NF-B transcription factor, which has major functions in gene regulation in response to inflammatory stimuli of the immune system. In this system, transcription is controlled though regulated proteolysis of the IB inhibitory proteins. In screening proteins that interact with IB, Fenwick et al. detected a protein they call B-Ras1 because of its similarity to the small guanosine triphosphatase Ras. The B-Ras1 protein is unusual in that it has mutations similar to those found in oncogenic mutants of Ras. The B-Ras1 and IB proteins were shown to interact in intact cells. Overexpression of B-Ras1 decreased degradation of IB proteins in cells and consequently decreased NF-B-dependent transcription. The B-Ras1 protein appears to associate specifically with complexes of NF-B with IBβ, which may explain why IBβ is degraded more slowly than is IBα.
Citation: Ras Proteins and IB Degradation. Sci. STKE 2000, tw8 (2000).
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