Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.


Sci. STKE, 8 February 2000
Vol. 2000, Issue 18, p. tw8
[DOI: 10.1126/stke.2000.18.tw8]

EDITORS' CHOICE

Transcriptional Regulation Ras Proteins and I{kappa}B Degradation

The I{kappa}B proteins are inhibitors of the NF-{kappa}B transcription factor, which has major functions in gene regulation in response to inflammatory stimuli of the immune system. In this system, transcription is controlled though regulated proteolysis of the I{kappa}B inhibitory proteins. In screening proteins that interact with I{kappa}B, Fenwick et al. detected a protein they call {kappa}B-Ras1 because of its similarity to the small guanosine triphosphatase Ras. The {kappa}B-Ras1 protein is unusual in that it has mutations similar to those found in oncogenic mutants of Ras. The {kappa}B-Ras1 and I{kappa}B proteins were shown to interact in intact cells. Overexpression of {kappa}B-Ras1 decreased degradation of I{kappa}B proteins in cells and consequently decreased NF-{kappa}B-dependent transcription. The {kappa}B-Ras1 protein appears to associate specifically with complexes of NF-{kappa}B with I{kappa}Bβ, which may explain why I{kappa}Bβ is degraded more slowly than is I{kappa}Bα.

Fenwick, C., Na, S.-Y., Voll, R.E., Zhong, H., Im, S.-Y., Lee, J.W., and Ghosh, S. (2000) A subclass of Ras proteins that regulate the degradation of I{kappa}B. Science 287: 869-873. [Abstract] [Full Text]

Citation: Ras Proteins and I{kappa}B Degradation. Sci. STKE 2000, tw8 (2000).


To Advertise     Find Products


Science Signaling. ISSN 1937-9145 (online), 1945-0877 (print). Pre-2008: Science's STKE. ISSN 1525-8882