Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.

Sci. STKE, 29 February 2000
Vol. 2000, Issue 21, p. tw5
[DOI: 10.1126/stke.2000.21.tw5]


Apoptosis Holding Back a Death Signal

In the worm Caenorhabditis elegans certain genes are critical for the timed death of a cell during development. How the protein products from these genes regulate one another in vivo is not clear. Chen et al. report that the pro-death protein CED-4 is translocated from the mitochondria (where it colocalizes with the anti-death protein CED-9) to the perinuclear membrane upon receipt of a death signal, such as expression of the pro-death protein EGL-1. The movement of CED-4 to the perinuclar membrane did not depend upon caspases and was a prerequisite for normal death, which suggests that the role of CED-9 may be to sequester CED-4 at the mitochondria until the appropriate developmental time for cell death.

Chen, F., Hersh, B.M., Conradt, B., Zhou, Z., Riemer, D., Gruenbaum, Y., and Horvitz, H.R. (2000) Translocation of C. elegans CED-4 to nuclear membranes during programmed cell death. Science 287: 1485-1489. [Abstract] [Full Text]

Citation: Holding Back a Death Signal. Sci. STKE 2000, tw5 (2000).

To Advertise     Find Products

Science Signaling. ISSN 1937-9145 (online), 1945-0877 (print). Pre-2008: Science's STKE. ISSN 1525-8882