Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.

Sci. STKE, 7 March 2000
Vol. 2000, Issue 22, p. tw3
[DOI: 10.1126/stke.2000.22.tw3]


Receptor Biology Calcyon, A New Dopamine Receptor Partner

Dopamine receptors have been intensively studied because of their central role in normal brain function and their involvement in a number of central nervous system diseases. Lezcano et al. show that the D1 dopamine receptor interacts with a newly identified transmembrane protein named Calcyon. Ultrastructural analysis reveals a close association between Calcyon and a specific D1 receptor subpopulation. They further show that Calcyon is a potential GTPase that mediates dopamine receptor-coupled signal transduction mechanisms. This finding may shed new light on the function of D1 receptors in the prefrontal cortex of the brain and their involvement in cognition and may also lead to new pharmacological approaches for the treatment of schizophrenia and other cognitive disorders.

Lezcano, N., Mrzljak, L., Eubanks, S., Levenson, R., Goldman-Rakic, P., and Bergson, C. (2000) Dual signaling regulated by Calcyon, a D1 dopamine receptor interacting protein. Science 287: 1660-1664. [Abstract] [Full Text]

Citation: Calcyon, A New Dopamine Receptor Partner. Sci. STKE 2000, tw3 (2000).

To Advertise     Find Products

Science Signaling. ISSN 1937-9145 (online), 1945-0877 (print). Pre-2008: Science's STKE. ISSN 1525-8882