Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.


Sci. STKE, 21 March 2000
Vol. 2000, Issue 24, p. tw11
[DOI: 10.1126/stke.2000.24.tw11]

EDITORS' CHOICE

Cell Differentiation Lhasa Proteins Try, but Only T-bet Matters

Naïve T helper lymphocytic cells differentiate into Th1 and Th2 cells, and they are defined by the cytokines they produce. The transcription factors GATA-3 and c-Maf are important for Th2 differentiation, but the components that cause Th1 differentiation are less well defined. Szabo et al. have identified a protein, T-bet (T box expressed in T cells), that directs the differentiation of T helper cells into the Th1 subtype. T-bet expression was observed in Th1 but not Th2 cells, and expression of T-bet was increased after engagement of the T cell receptor. The authors found that T-bet strongly increased interferon (IFN) gamma expression, a marker for Th1 differentiation. Also, forced expression of T-bet in Th2 cells considered to be completely differentiated redirected the Th2 cells into the Th1 phenotype, as measured by decreases in interleukin (IL)-5 and IL-4 production. However, the decrease in IL-5 production was much more pronounced than the decrease in IL-4 production. Although IL-5 expression is very much dependent on the transcriptional activity of GATA-3, IL-4 expression depends on the concerted activity of several transcription factors including GATA-3. Thus, the authors speculate that one function of T-bet may be to directly inhibit GATA-3 activity and to redirect differentiation to the Th1 pathway.

Szabo, S.J., Kim, S.T., Costa, G.L., Zhang, X., Garrison Fathman, C., and Glimcher, L.H. (2000) A novel transcription factor, T-bet, directs Th1 lineage commitment. Cell 100: 655-669. [Online Journal]

Citation: Lhasa Proteins Try, but Only T-bet Matters. Sci. STKE 2000, tw11 (2000).


To Advertise     Find Products


Science Signaling. ISSN 1937-9145 (online), 1945-0877 (print). Pre-2008: Science's STKE. ISSN 1525-8882