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Sci. STKE, 18 April 2000
Vol. 2000, Issue 28, p. tw10
[DOI: 10.1126/scisignal.282000tw10]

EDITORS' CHOICE

Immunology A Kinase Upstream of IKK

Tojima et al. identified NF-{kappa}B-activating kinase, NAK, based on homology to IKKα and IKKβ, which forms a complex that phosphorylates I{kappa}B and leads to I{kappa}B degradation and the activation of the NF-{kappa}B transcription factor. Despite sequence similarity, the authors propose that NAK functions in NF-{kappa}B activation upstream of IKK, because NAK appears to activate NF-{kappa}B through phosphorylation of IKKβ. Activation of NAK appears to be specifically mediated by stimuli that activate protein kinase C {epsilon}. The authors propose that NAK functions downstream of PKC{epsilon} and upstream of IKK to stimulate NF-{kappa}B activity.

Tojima, Y., Fujimoto, A., Delhase, M., Chen, Y., Hatakeyama, S., Nakayama, K.-i., Kaneko, Y., Nimura, Y., Motoyama, N., Ikeda, K., Karin, M., Nakanishi, M. (2000) NAK is an I{kappa}B kinase-activating kinase. Nature 404: 778-782. [Online Journal]

Citation: A Kinase Upstream of IKK. Sci. STKE 2000, tw10 (2000).

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