Sci. STKE, 18 April 2000
Immunology A Kinase Upstream of IKK
Tojima et al. identified NF-B-activating kinase, NAK, based on homology to IKKα and IKKβ, which forms a complex that phosphorylates IB and leads to IB degradation and the activation of the NF-B transcription factor. Despite sequence similarity, the authors propose that NAK functions in NF-B activation upstream of IKK, because NAK appears to activate NF-B through phosphorylation of IKKβ. Activation of NAK appears to be specifically mediated by stimuli that activate protein kinase C . The authors propose that NAK functions downstream of PKC and upstream of IKK to stimulate NF-B activity.
Tojima, Y., Fujimoto, A., Delhase, M., Chen, Y., Hatakeyama, S., Nakayama, K.-i., Kaneko, Y., Nimura, Y., Motoyama, N., Ikeda, K., Karin, M., Nakanishi, M. (2000) NAK is an IB kinase-activating kinase. Nature 404: 778-782. [Online Journal]
Citation: A Kinase Upstream of IKK. Sci. STKE 2000, tw10 (2000).
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