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Sci. STKE, 16 May 2000
Vol. 2000, Issue 32, p. tw2
[DOI: 10.1126/scisignal.322000tw2]

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Calcium Presenilin and Calcium Channel Regulation

Disruption of intracellular calcium homeostasis is a consequence of some mutations that arise in the integral membrane protein presenilin 2 (PS2) in familial Alzheimer's disease (FAD). Pack-Chung et al. report that a hydrophilic loop region of PS2 interacts with sorcin, a cytoplasmic calcium-binding protein that modulates the ryanodine receptor intracellular calcium channel. Sorcin-PS2 complexes were isolated from human brain tissue, and an increase in intracellular calcium stimulated sorcin translocation to membranes and sorcin-PS2 interaction in cultured cells. The authors suggest that sorcin, PS2, and the ryanodine receptor may comprise a molecular complex that modulates intracellular calcium and may thus play a role in FAD pathology.

Pack-Chung, E., Meyers, M.B., Pettingell, W.P., Moir, R.D., Brownawell, A.M., Cheng, I., Tanzi, R.E., and Kim, T.-W. (2000) Presenilin 2 interacts with sorcin, a modulator of the ryanodine receptor. J. Biol. Chem. 275: 14440-14445. [Abstract] [Full Text]

Citation: Presenilin and Calcium Channel Regulation. Sci. STKE 2000, tw2 (2000).

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Science Signaling. ISSN 1937-9145 (online), 1945-0877 (print). Pre-2008: Science's STKE. ISSN 1525-8882