Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.


Sci. STKE, 16 May 2000
Vol. 2000, Issue 32, p. tw2
[DOI: 10.1126/stke.2000.32.tw2]

EDITORS' CHOICE

Calcium Presenilin and Calcium Channel Regulation

Disruption of intracellular calcium homeostasis is a consequence of some mutations that arise in the integral membrane protein presenilin 2 (PS2) in familial Alzheimer's disease (FAD). Pack-Chung et al. report that a hydrophilic loop region of PS2 interacts with sorcin, a cytoplasmic calcium-binding protein that modulates the ryanodine receptor intracellular calcium channel. Sorcin-PS2 complexes were isolated from human brain tissue, and an increase in intracellular calcium stimulated sorcin translocation to membranes and sorcin-PS2 interaction in cultured cells. The authors suggest that sorcin, PS2, and the ryanodine receptor may comprise a molecular complex that modulates intracellular calcium and may thus play a role in FAD pathology.

Pack-Chung, E., Meyers, M.B., Pettingell, W.P., Moir, R.D., Brownawell, A.M., Cheng, I., Tanzi, R.E., and Kim, T.-W. (2000) Presenilin 2 interacts with sorcin, a modulator of the ryanodine receptor. J. Biol. Chem. 275: 14440-14445. [Abstract] [Full Text]

Citation: Presenilin and Calcium Channel Regulation. Sci. STKE 2000, tw2 (2000).


To Advertise     Find Products


Science Signaling. ISSN 1937-9145 (online), 1945-0877 (print). Pre-2008: Science's STKE. ISSN 1525-8882