Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.


Sci. STKE, 30 May 2000
Vol. 2000, Issue 34, p. tw5
[DOI: 10.1126/stke.2000.34.tw5]

EDITORS' CHOICE

Transcription Factors Regulating Physiology is PPAR for the Course

Peroxisome proliferator-activated receptors (PPARs) are ligand-dependent transcription factors that have a role in diseases associated with obesity. Unsaturated long-chain fatty acids and eicosanoids are known to act as ligands with different affinities for the three PPAR isotypes: α, β (or {delta}), and {gamma}. Kersten et al. review the role of each PPAR isotype in normal and abnormal processes and discuss the potential for treating chronic disease states by administering synthetic PPAR ligands. However, the controversy stemming from recent clinical reports on the toxicity of the PPAR agonist Rezulin (troglitazone) indicates that more work is required to develop potentially less harmful PPAR agonists for chronic disease therapy.

Kersten, S., Desvergne, B., and Wahli, W. (2000) Roles of PPARs in health and disease. Nature 405: 421-424. [Online Journal]

Citation: Regulating Physiology is PPAR for the Course. Sci. STKE 2000, tw5 (2000).


To Advertise     Find Products


Science Signaling. ISSN 1937-9145 (online), 1945-0877 (print). Pre-2008: Science's STKE. ISSN 1525-8882