Sci. STKE, 30 May 2000
Immunology To B Cell, or Not to B Cell
The transcription factor PU.1 is essential in B cell and macrophage development and proliferation. DeKoter and Singh show that the level of expression of PU.1 can control which cell fate will result. At low levels, PU.1 protein caused precursor cells to differentiate into B lymphocytes; whereas at high levels of PU.1, the same cells differentiated into macrophages.
Citation: To B Cell, or Not to B Cell. Sci. STKE 2000, tw7 (2000).
Science Signaling. ISSN 1937-9145 (online), 1945-0877 (print). Pre-2008: Science's STKE. ISSN 1525-8882