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Sci. STKE, 30 May 2000
Vol. 2000, Issue 34, p. tw7
[DOI: 10.1126/scisignal.342000tw7]

EDITORS' CHOICE

Immunology To B Cell, or Not to B Cell

The transcription factor PU.1 is essential in B cell and macrophage development and proliferation. DeKoter and Singh show that the level of expression of PU.1 can control which cell fate will result. At low levels, PU.1 protein caused precursor cells to differentiate into B lymphocytes; whereas at high levels of PU.1, the same cells differentiated into macrophages.

DeKoter, R.P., and Singh, H. (2000) Regulation of B lymphocyte and macrophage development by graded expression of PU.1. Science 288: 1439-1441. [Abstract] [Full Text]

Citation: To B Cell, or Not to B Cell. Sci. STKE 2000, tw7 (2000).

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