Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.


Sci. STKE, 6 June 2000
Vol. 2000, Issue 35, p. tw6
[DOI: 10.1126/stke.2000.35.tw6]

EDITORS' CHOICE

Immunology LAT is Important for Fc{epsilon}RI Signaling

The linker protein LAT functions as a signaling network hub where several proteins bind and become activated. The importance of LAT in T cell-receptor signaling is well documented; however, the role of LAT in other immune cells has not been so intensively examined. Saitoh et al. show that LAT has an important function in Fc{epsilon}RI signaling in mast cells. Mast cells derived from LAT-deficient mice are able to partially signal through Fc{epsilon}RI cross-linking and can activate Syk and Vav; however, activation of SLP-76, of both isoforms of PLC-{gamma}, and of specific MAPK pathways was greatly reduced. In addition, Ca2+ mobilization, exocytotic degranulation, and the expression of several cytokines were impaired in LAT-deficient mast cells. These results suggest that LAT is important for proper signaling by Fc{epsilon}RI and for physiological responses to antigens.

Saitoh, S., Arudchandran, R., Manetz, T.S., Zhang, W., Sommers, C.L., Love, P.E., Rivera, J., and Samelson, L.E. (2000) LAT is essential for Fc{epsilon}RI-mediated mast cell activation. Immunity 12: 525-535. [Online Journal]

Citation: LAT is Important for Fc{epsilon}RI Signaling. Sci. STKE 2000, tw6 (2000).


To Advertise     Find Products


Science Signaling. ISSN 1937-9145 (online), 1945-0877 (print). Pre-2008: Science's STKE. ISSN 1525-8882