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Sci. STKE, 6 June 2000
Vol. 2000, Issue 35, p. tw6
[DOI: 10.1126/scisignal.352000tw6]

EDITORS' CHOICE

Immunology LAT is Important for Fc{epsilon}RI Signaling

The linker protein LAT functions as a signaling network hub where several proteins bind and become activated. The importance of LAT in T cell-receptor signaling is well documented; however, the role of LAT in other immune cells has not been so intensively examined. Saitoh et al. show that LAT has an important function in Fc{epsilon}RI signaling in mast cells. Mast cells derived from LAT-deficient mice are able to partially signal through Fc{epsilon}RI cross-linking and can activate Syk and Vav; however, activation of SLP-76, of both isoforms of PLC-{gamma}, and of specific MAPK pathways was greatly reduced. In addition, Ca2+ mobilization, exocytotic degranulation, and the expression of several cytokines were impaired in LAT-deficient mast cells. These results suggest that LAT is important for proper signaling by Fc{epsilon}RI and for physiological responses to antigens.

Saitoh, S., Arudchandran, R., Manetz, T.S., Zhang, W., Sommers, C.L., Love, P.E., Rivera, J., and Samelson, L.E. (2000) LAT is essential for Fc{epsilon}RI-mediated mast cell activation. Immunity 12: 525-535. [Online Journal]

Citation: LAT is Important for Fc{epsilon}RI Signaling. Sci. STKE 2000, tw6 (2000).

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