Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.
Science Career Fair

Site Tools

  • AAAS
  • Subscribe
  • Feedback

Site Search

Search Advanced

Sci. STKE, 13 June 2000
Vol. 2000, Issue 36, p. tw3
[DOI: 10.1126/stke.2000.36.tw3]

EDITORS' CHOICE

DEVELOPMENTAL BIOLOGY A Matter of Efficiency

Abstract:

The Wnt family of signaling proteins plays key roles in a variety of embryonic inductive events in vertebrates and invertebrates. This diversity appears to be mediated by differences in Frizzled (Fz) proteins, the cell-surface receptors for Wnt. Boutros et al. examined two Drosophila Fz proteins and found that, while they both activate the same signaling pathways, they do so with different efficiencies. The cytoplasmic domains of the receptors are largely accountable for this difference. Factored with differences in receptor-ligand affinities, this domain may be important in determining specific signaling outcomes.

Boutros, M., Mihaly, J., Bouwmeester, T., and Mlodzik, M. (2000) Signaling specificity by Frizzled receptors in Drosophila. Science 288: 1825-1828. [Abstract] [Full Text]

Citation: A Matter of Efficiency. Sci. STKE 2000, tw3 (2000).

Read the Full Text

ADVERTISEMENT
Click Me!

ADVERTISEMENT
Click Me!

To Advertise     Find Products

Science Signaling. ISSN 1937-9145 (pre-2008: Science's STKE. ISSN 1525-8882)