Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.


Sci. STKE, 4 July 2000
Vol. 2000, Issue 39, p. tw11
[DOI: 10.1126/stke.2000.39.tw11]

EDITORS' CHOICE

Receptor Biology An Earful of AChR α9

Even before hearing becomes active, there is a transient cholinergic innervation in the developing mammalian inner ear. The physiological significance of these synapses has never been demonstrated. Glowatzki and Fuchs show that the novel neuronal nicotinic acetylcholine receptor α9 is functionally present in neonatal cochlear inner hair cells and behaves like a true acetylcholine receptor. Its stimulation results in the activation of a fast, calcium-dependent potassium channel. Acetylcholine thus inhibits afferent activity and acts to impose rhythmicity onto the immature auditory pathway.

Glowatzki, E., and Fuchs, P.A. (2000) Cholinergic synaptic inhibition of inner hair cells in the neonatal mammalian cochlea. Science 288: 2366-2368. [Abstract] [Full Text]

Citation: An Earful of AChR α9. Sci. STKE 2000, tw11 (2000).


To Advertise     Find Products


Science Signaling. ISSN 1937-9145 (online), 1945-0877 (print). Pre-2008: Science's STKE. ISSN 1525-8882