Sci. STKE, 4 July 2000
Apoptosis Survival in Developing Immune Systems
Proper development of the immune system requires complicated controls of the development of thymocytes and selection of functional T cells through positive and negative selection. Sun et al. examined the role of the retinoic acid receptor-related orphan receptor (ROR) in development of the mouse immune system. Their studies of animals that lacked ROR indicate that ROR enhances survival of thymocytes by promoting the expression of the anti-apoptotic protein Bcl-xL. The knockout animals lacked lymph nodes and Peyer's patches, apparently because of failed development of the CD4+ progenitor cells required for normal development of these structures. The authors propose that regulation of ROR signals might modulate expression of Bcl-xL and thus control "death by neglect" of thymocytes that fail to interact productively with peptide-MHC complexes.
Sun, Z., Unutmaz, D., Zou, Y.-R., Sunshine, M.J., Pierani, A., Brenner-Morton, S., Mebius, R.E., and Littman, D.R. (2000) Requirement for ROR in thymocyte survival and lymphoid organ development. Science 288: 2369-2373. [Abstract] [Full Text]
Citation: Survival in Developing Immune Systems. Sci. STKE 2000, tw8 (2000).
Science Signaling. ISSN 1937-9145 (online), 1945-0877 (print). Pre-2008: Science's STKE. ISSN 1525-8882