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Sci. STKE, 11 July 2000
Vol. 2000, Issue 40, p. pe1
[DOI: 10.1126/stke.2000.40.pe1]

PERSPECTIVES

Multiple Calcium Stores: Separate but Interacting

Hon Cheung Lee

The author is at the Department of Pharmacology, University of Minnesota, Minneapolis, MN 55455, USA. E-mail: leehc{at}tc.umn.edu

Abstract: Multiple mechanisms exist for increasing the concentration of intracellular calcium. This Perspective by Lee is one in a series on intracellular calcium release mechanisms and focuses on the calcium store operated by nicotinic acid adenine dinucleotide phosphate (NAADP). The characterization of the NAADP-operated calcium store as separate from the inositol trisphosphate (IP3)-operated and cyclic ADP-ribose (cADPR)-operated calcium stores is discussed. Lee also addresses the role of NAADP in regulating intracellular calcium fluctuations during fertilization and hormonal activation of pancreatic acinar cells.

Citation: H. C. Lee, Multiple Calcium Stores: Separate but Interacting. Sci. STKE 2000, pe1 (2000).

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NAADP: A Universal Ca2+ Trigger.
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