Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.


Sci. STKE, 11 July 2000
Vol. 2000, Issue 40, p. tw3
[DOI: 10.1126/stke.2000.40.tw3]

EDITORS' CHOICE

Apoptosis Mighty Deadly MyD88

Toll receptors are activated by bacterially produced pathogen-associated molecular pattern (PAMPs). Bacterial lipoproteins (BLPs) are PAMPs that activate the Toll-like receptor 2 (TLR2) through recruitment of the adaptor molecule MyD88. Transfection of a variety of dominant negative mutants allowed Aliprantis et al. to show that MyD88 is a common mediator for both the cell survival signal mediated by NF-{kappa}B activation and the apoptotic signal mediated through Fas-associated death domain protein (FADD). FADD activation is dependent on the death domain (DD) of MyD88, and the two proteins could be coimmunoprecipitated from transfected cells, confirming a physical interaction between them. Apoptosis was inhibited by mutant forms of caspase 8, FADD, or MyD88, confirming an apoptosis pathway from TLR2 to MyD88 to FADD to caspase 8.

Aliprantis, A.O., Yang, R.-B., Weiss, D.S., Godowski, P., and Zychlinsky, A. (2000) The apoptotic signaling pathway activated by Toll-like receptor-2. EMBO J. 19: 3325-3336. [Abstract] [Full Text]

Citation: Mighty Deadly MyD88. Sci. STKE 2000, tw3 (2000).


To Advertise     Find Products


Science Signaling. ISSN 1937-9145 (online), 1945-0877 (print). Pre-2008: Science's STKE. ISSN 1525-8882