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Sci. STKE, 18 July 2000
Vol. 2000, Issue 41, p. pe1
[DOI: 10.1126/stke.2000.41.pe1]


Cyclic ADP Ribose as a Calcium-Mobilizing Messenger

Antony Galione and Grant C. Churchill

The authors are at the University of Oxford, Department of Pharmacology, Mansfield Road, Oxford OX1 3QT, UK.

Abstract: This Perspective by Galione and Churchill is one in a series on intracellular calcium release mechanisms. The authors review the evidence for cyclic adenosine diphosphate ribose (cADPR) being a second messenger involved in regulating intracellular calcium. In addition, the physiological stimuli and responses mediated by cADPR are discussed. The Perspective is accompanied by a movie showing a calcium wave triggered by cADPR.

Citation: A. Galione, G. C. Churchill, Cyclic ADP Ribose as a Calcium-Mobilizing Messenger. Sci. STKE 2000, pe1 (2000).

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An NAADP-gated Two-pore Channel Targeted to the Plasma Membrane Uncouples Triggering from Amplifying Ca2+ Signals.
E. Brailoiu, T. Rahman, D. Churamani, D. L. Prole, G. C. Brailoiu, R. Hooper, C. W. Taylor, and S. Patel (2010)
J. Biol. Chem. 285, 38511-38516
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