Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.


Sci. STKE, 18 July 2000
Vol. 2000, Issue 41, p. tw1
[DOI: 10.1126/stke.2000.41.tw1]

EDITORS' CHOICE

Lipid Signaling Lipid Signals Prevent a Broken Heart

Kupperman et al. characterized the miles apart (mil) gene in zebrafish, which encodes a G protein-coupled receptor with sequence similarity to sphinosine-1-phosphate (S1P) receptors. Mutations in mil cause defects in the migration of cardiac precursor cells without affecting differentiation and lead to the formation of two laterally positioned hearts. Using transgenic methods, the authors show that mil expression was not required in the precursor cells themselves but was critical for establishing a signal or environment allowing proper migration. Confirmation that Mil is an S1P receptor came from the ability of S1P to stimulate calcium transients and to activate MAP kinase cascades in cells transfected to express mil. The data provide evidence for a role for lysosphingolipids in embryogenesis and signaling cell migration.

Kupperman, E., An, S., Osborne, N., Waldron, S., and Stainler, D.Y.R. (2000) A sphingosine-1-phosphate receptor regulates cell migration during vertebrate heart development. Nature 406: 192-195. [Online Journal]

Citation: Lipid Signals Prevent a Broken Heart. Sci. STKE 2000, tw1 (2000).


To Advertise     Find Products


Science Signaling. ISSN 1937-9145 (online), 1945-0877 (print). Pre-2008: Science's STKE. ISSN 1525-8882