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Sci. STKE, 25 July 2000
Vol. 2000, Issue 42, p. pe1
[DOI: 10.1126/stke.2000.42.pe1]

PERSPECTIVES

Steroid Receptor and Molecular Chaperone Encounters in the Nucleus

Donald B. DeFranco and Peter Csermely

D. B. DeFranco is in the Department of Pharmacology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, USA. E-mail: dod1+{at}pitt.edu
P. Csermely is in the Department of Medical Chemistry, Semmelweis University, Budapest, Hungary. E-mail: csermely{at}puskin.sote.hu

Abstract: Steroid hormone receptors interact with several different molecular chaperones. DeFranco and Csermely discuss how the molecular chaperones p23 and Hsp90 may serve to regulate the activity of the ligand-bound steroid receptors within the nucleus. The authors hypothesize that these chaperone proteins may have a proactive role in promoting recycling of receptors once they have interacted with chromatin and in allowing rebinding of ligand once the receptors have been recycled.

Citation: D. B. DeFranco, P. Csermely, Steroid Receptor and Molecular Chaperone Encounters in the Nucleus. Sci. STKE 2000, pe1 (2000).

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