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Sci. STKE, 1 August 2000
Vol. 2000, Issue 43, p. tw5
[DOI: 10.1126/scisignal.432000tw5]

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Virology Blocking Apoptosis Leads to Necrosis

Li and Beg show that cells infected with viruses that express inhibitors of caspases or cells treated with peptidyl caspase inhibitors exhibit a necrotic cell death in response to tumor necrosis factor-α (TNF-α), double-stranded RNA, or interferon {gamma}. Necrosis was dependent on the production of superoxides by the mitochondria and was inhibited by mitochondrial complex I and II inhibitors or antioxidants. Thus, a virus may evade triggering apoptosis, but a necrotic pathway may still lead to the infected cell's demise.

Li, M., and Beg, A.A., (2000) Induction of necrotic-like cell death by tumor necrosis factor alpha and caspase inhibitors: Novel mechanism for killing virus-infected cells. J. Virol. 74: 7470-7477. [Abstract] [Full Text]

Citation: Blocking Apoptosis Leads to Necrosis. Sci. STKE 2000, tw5 (2000).

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Science Signaling. ISSN 1937-9145 (online), 1945-0877 (print). Pre-2008: Science's STKE. ISSN 1525-8882