Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.


Sci. STKE, 15 August 2000
Vol. 2000, Issue 45, p. tw6
[DOI: 10.1126/stke.2000.45.tw6]

EDITORS' CHOICE

Neurobiology A Phosphate Transporter Also Hauls Glutamate

One of the most important neurotransmitters, glutamate, has long held a secret from the research community -- the identity of its transporter into synaptic vesicles. Bellochio et al. (see the news story by Helmuth) now report that a protein previously thought to play a role in transporting inorganic phosphate across the plasma membrane, the brain-specific Na+-dependent inorganic phosphate transporter (BNPI), also acts as the glutamate transporter. Now bearing a second moniker, the vesicular glutamate transporter (VGLUT1), its role may be a function of its environment. The authors suggest that at the plasma membrane, it may function as BNPI, whereas in synaptic vesicles it functions as VGLUT1.

Bellocchio, E.E., Reimer, R.J., Fremeau, R.T. Jr., and Edwards, R.H. (2000) Uptake of glutamate into synaptic vesicles by an inorganic phosphate transporter. Science 289: 957-960. [Abstract] [Full Text]

Helmuth, L. (2000) Long-sought protein packages glutamate. Science 289: 847-849. [Abstract] [Full Text]

Citation: A Phosphate Transporter Also Hauls Glutamate. Sci. STKE 2000, tw6 (2000).


To Advertise     Find Products


Science Signaling. ISSN 1937-9145 (online), 1945-0877 (print). Pre-2008: Science's STKE. ISSN 1525-8882