Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.


Sci. STKE, 22 August 2000
Vol. 2000, Issue 46, p. tw3
[DOI: 10.1126/stke.2000.46.tw3]

EDITORS' CHOICE

Neurobiology Reelin Multimers

Reelin is a secreted protein that regulates neuron localization during development of the mammalian brain. Utsunomiya-Tate et al. analyzed neuronal cell lysates and culture media and found that Reelin forms large protein complexes of various sizes. An antibody known to bind to the amino-terminus of Reelin and to inhibit its biological activity also inhibited formation of Reelin multimers. Isolated epitope fragments of Reelin formed a linear, soluble polymer whose interaction is electrostatic in nature. A mutant form of Reelin lacking the epitope region did not form polymers nor could it transduce signals through Reelin receptors. The authors propose that the Reelin multimer may induce receptor oligomerization, although the size of the biologically active multimer is not yet known.

Utsunomiya-Tate, N., Kubo, K., Tate, S., Kainosho, M., Katayama, E., Nakajima, K., and Mikoshiba, K. (2000) Reelin molecules assemble together to form a large protein complex, which is inhibited by the function-blocking CR-50 antibody. Proc. Natl. Acad. Sci. U.S.A. 97: 9729-9734. [Abstract] [Full Text]

Citation: Reelin Multimers. Sci. STKE 2000, tw3 (2000).


To Advertise     Find Products


Science Signaling. ISSN 1937-9145 (online), 1945-0877 (print). Pre-2008: Science's STKE. ISSN 1525-8882