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Sci. STKE, 29 August 2000
Vol. 2000, Issue 47, p. tw10
[DOI: 10.1126/scisignal.472000tw10]

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Immunology Imaging Immunological Synapses

Immunological synapses arise at contact zones between antigen-presenting cells and T cells. Synapses have distinct organization and are composed of T cell receptors interacting with major histocompatibility complex-peptide entities surrounded by various potentiating coreceptors and signaling molecules that migrate into the synapse through cytoskeleton-dependent processes. Krummel et al. have extended initial studies in lipid bilayers to explore the architecture and the extraordinary dynamics of immunological synapse formation by real-time video microscopy of whole cells containing green fluorescent protein chimeras.

Krummel, M.F., Sjaastad. M.D., Wülfing, C., and David, M.M. (2000) Differential clustering of CD4 and CD3{zeta} during T cell recognition. Science 289: 1349-1352. [Abstract] [Full Text]

Citation: Imaging Immunological Synapses. Sci. STKE 2000, tw10 (2000).

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