Sci. STKE, 29 August 2000
Neurobiology When the Attraction Is Gone
Environmental cues that are attractive or repulsive tell a migrating axon where to go by sending signals through the appropriate cell surface receptors. How is it then that for retraction to occur, a cell surface receptor must first engage with the repulsion factor and then overcome the adhesive force? Hattori et al. and Galko and Tessier-Lavigne report that these interactions can be broken by metalloprotease enzymes that result in the release of the axon from its captor. In a Perspective, Pasquale discusses how the involvement of cell surface metalloproteases in regulating axon guidance is a compelling solution to this puzzling paradox.
Pasquale, E. (2000) Turning attraction into repulsion. Science 289: 1308-1310. [Full Text]
Citation: When the Attraction Is Gone. Sci. STKE 2000, tw2 (2000).
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