Sci. STKE, 29 August 2000
Cancer Biology Fateful Fusion
Chromosomal translocations that produce oncogenic fusion proteins are common in leukemias and soft-tissue tumors but have rarely been observed in solid tumors (carcinomas), which account for 90% of all cancers. In a study of human thyroid follicular carcinomas, Kroll et al. identified a common translocation that fuses the DNA binding region of the PAX8 transcription factor to peroxisome proliferator protein receptor 1 (PPAR1), a member of the nuclear hormone receptor superfamily. The fusion protein inhibited transcriptional transactivation by PPAR1 in a dominant-negative manner. Discovery of this fusion event opens up new possibilities for diagnosis and treatment of thyroid cancer.
Kroll, T.G., Sarraf, P., Pecciarini, L., Chen, C.-J., Mueller, E., Spiegelman, B.M., and Fletcher, J.A. (2000) PAX8-PPAR1 fusion in oncogene human thyroid carcinoma. Science 289: 1357-1360. [Abstract] [Full Text]
Citation: Fateful Fusion. Sci. STKE 2000, tw3 (2000).
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