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Sci. STKE, 5 September 2000
Vol. 2000, Issue 48, p. pe1
[DOI: 10.1126/stke.2000.48.pe1]


MAP Kinases and the Regulation of Nuclear Receptors

John M. Kyriakis

The author is at the Diabetes Research Laboratory, Massachusetts General Hospital East, 149 13th Street, Charlestown, MA 02129, USA. E-mail: kyriakis{at}

Abstract: The activity of nuclear receptors or ligand-activated transcription factors can be regulated both positively and negatively by signals transduced through mitogen-activated protein kinase (MAPK) signaling cascades. Kyriakis discusses how cross talk between MAPK signaling and nuclear receptor signaling occurs and the effect this cross talk has on nuclear receptor function.

Citation: J. M. Kyriakis, MAP Kinases and the Regulation of Nuclear Receptors. Sci. STKE 2000, pe1 (2000).

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