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Sci. STKE, 28 November 2000
Vol. 2000, Issue 60, p. pe1
[DOI: 10.1126/stke.2000.60.pe1]


Dueling Enigmas: Neurosteroids and Sigma Receptors in the Limelight

Terrell T. Gibbs and David H. Farb

The authors are in the Laboratory of Molecular Neurobiology, Department of Pharmacology, Boston University School of Medicine, 715 Albany Street, Boston, MA 02118, USA. E-mail: tgibbs{at}; dfarb{at}

Abstract: Neurosteroids can be positive or negative regulators of neurotransmitter receptor action, depending on the receptor and the chemical structure of the neurosteroid. This Perspective by Gibbs and Farb is one of two on the subject of neurosteroids. The authors address the possible role of {sigma} receptors in mediating neurosteroid action and describe how the regulation of inhibitory and excitatory ion channels by neurosteroids has implications for the role of these molecules in learning and memory, nociception, and excitotoxicity.

Citation: T. T. Gibbs, D. H. Farb, Dueling Enigmas: Neurosteroids and Sigma Receptors in the Limelight. Sci. STKE 2000, pe1 (2000).

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