Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.


Sci. STKE, 12 December 2000
Vol. 2000, Issue 62, p. tw4
[DOI: 10.1126/stke.2000.62.tw4]

EDITORS' CHOICE

Cell Biology More than Light Work

Rhodopsin, one of the proteins responsible for sensing light in the eye, is also important in the generation of photoreceptor cells--photoreceptors that lack rhodopsin degenerate. Chang and Ready managed to prevent photoreceptor degeneration in Drosophila lacking rhodopsin by expressing a constitutively active form of a Rho guanosine triphosphatase, Drac1. It appears that Drac1 organizes the actin cytoskeleton in the developing photoreceptor cells. Rhodopsin appears to play an additional role beyond sensory perception, in that it activates a signal transduction pathway to stimulate morphogenesis during development. Colley provides a perspective on the data.

Chang, H.-Y., and Ready, D.F. (2000) Rescue of photoreceptor degeneration in rhodopsin-null Drosophila mutants by activated Rac1. Science 290: 1978-1980. [Abstract] [Full Text]

Colley, N.J. (2000) Actin' up with Rac1. Science 290: 1902-1903. [Full Text]

Citation: More than Light Work. Sci. STKE 2000, tw4 (2000).


To Advertise     Find Products


Science Signaling. ISSN 1937-9145 (online), 1945-0877 (print). Pre-2008: Science's STKE. ISSN 1525-8882