Sci. STKE, 19 December 2000
Vol. 2000, Issue 63, p. pe2
[DOI: 10.1126/scisignal.632000pe2]
PERSPECTIVES
Positive Versus Negative Signaling of LET-23: Regulation Through the Adaptor Protein, SEM-5
Carolyn Worby and
Ben Margolis
C. Worby is in the Department of Biological Chemistry, University of Michigan Medical School, Ann Arbor, MI 48109, USA. E-mail: cdworby{at}umich.edu
B. Margolis is in the Department of Biological Chemistry and Department of Internal Medicine, University of Michigan Medical School, and the Howard Hughes Medical Institution, Ann Arbor, MI 48109, USA. E-mail: bmargoli{at}umich.edu
Abstract:
Worby and Margolis highlight advances in our understanding of signaling from growth factor receptors using the worm Caenorhabditis elegans as a model organism. ARK-1, a cytoplasmic tyrosine kinase, appears to be a negative regulator of multiple pathways in C. elegans. The authors discuss several models for how this negative regulation may occur. The adaptor protein (Grb2 in mammals or SEM-5 in C. elegans) may serve as a regulated scaffold for the binding of other signaling proteins that include both positive (Ras) and negative (ACK) regulators. Thus, Grb2 may function in a cellular decision point for transducing the incoming signals.
Citation: C. Worby, B. Margolis, Positive Versus Negative Signaling of LET-23: Regulation Through the Adaptor Protein, SEM-5. Sci. STKE 2000, pe2 (2000).
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