Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.


Sci. STKE, 19 December 2000
Vol. 2000, Issue 63, p. tw1
[DOI: 10.1126/stke.2000.63.tw1]

EDITORS' CHOICE

Receptor Biology An Orphan No More?

Nuclear receptors are a superfamily of proteins that function as ligand-activated transcription factors. Among these proteins are the so-called "orphan receptors," such as the retinoid X receptor (RXR), for which the endogenous activating ligands have not been identified. Using a cell-based screening assay, Mata de Urquiza et al. show that docosahexaenoic acid (DHA), an abundant polyunsaturated fatty acid in mammalian brain, is a potent activator of RXR. DHA deficiency has previously been linked to defects in spatial learning capacity in rodents. The new data raise the possibility that DHA's effects are mediated through an RXR signaling pathway.

Mata de Urquiza, A., Liu, S., Sjöberg, M., Zetterström, R., Griffiths, W., Sjövall, J., and Perlmann, T. (2000) Docosahexaenoic acid, a ligand for the retinoid X receptor in mouse brain. Science 290: 2140-2144. [Abstract] [Full Text]

Citation: An Orphan No More? Sci. STKE 2000, tw1 (2000).


To Advertise     Find Products


Science Signaling. ISSN 1937-9145 (online), 1945-0877 (print). Pre-2008: Science's STKE. ISSN 1525-8882