Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.

Sci. STKE, 19 December 2000
Vol. 2000, Issue 63, p. tw7
[DOI: 10.1126/stke.2000.63.tw7]


Cell Cycle Bacterial Cell Cycles

The array of genes that are expressed during the life cycle of a cell can be pictured as a complex genetic circuit. Laub et al. provide a global survey of the part of that circuit expressed during the cell cycle of Caulobacter crescentus, a bacterium that differentiates during the course of its life. Out of nearly 3000 genes, 553 show cell-cycle regulation. Temporal controls over genes involved in specific cell functions and coordinate regulation of proteins that are part of complexes were also observed. CtRA was shown to be a central regulator of the cell cycle in experiments with overexpressing or loss-of-function mutants. A histidine kinase and two RNA polymerase sigma factors were identified as possible regulators of early S phase.

Laub, M.T., McAdams, H.H., Feldblyum, T., Fraser, C.M., and Shapiro, L. (2000) Global analysis of the genetic network controlling a bacterial cell cycle. Science 290: 2144-2148. [Abstract] [Full Text]

Citation: Bacterial Cell Cycles. Sci. STKE 2000, tw7 (2000).

To Advertise     Find Products

Science Signaling. ISSN 1937-9145 (online), 1945-0877 (print). Pre-2008: Science's STKE. ISSN 1525-8882