Wnts, Signaling and Sulfates

Seth S. Blair

Department of Zoology, University of Wisconsin, 250 N. Mills St., Madison, WI 53706 USA. E-mail:ssblair{at}facstaff.wisc.edu

Contact information: phone: 608-262-1345, fax: 608-262-9083, E-mail: ssblair{at}facstaff.wisc.edu

Abstract: Questions remain about the signaling pathways that control pattern formation during development. Blair describes how sulfated glycosaminoglycans affect several developmentally important signaling pathways, including Wnt-Wingless, Fibroblast growth factor, Hedgehog, and Bone morphogenetic protein-4 signaling. A new secreted sulfatase, Qsulf1, regulates the sensitivity of vertebrate cells to Wnts, possibly by modifying the sulfation of glycosaminoglycans.

Citation:
S. S. Blair, Wnts, Signaling and Sulfates. Science's STKE (2001), http://stke.sciencemag.org/cgi/content/full/OC_sigtrans;2001/101/pe32.

© 2001 American Association for the Advancement of Science

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