Sci. STKE, 2 October 2001
Neurobiology Dendritic Spine Formation
Changes in the morphology of neuronal dendritic spines are correlated with changes in synaptic plasticity. The cell surface proteoglycan syndecan-2 is clustered at the surface of mature hippocampal neurons and is thought to regulate structural changes of the spines. Ethell et al. demonstrate that syndecan-2 is phosphorylated on at least two tyrosine residues by the receptor-type tyrosine kinase EphB2 in vitro and in vivo. The two transmembrane proteins colocalized in dendrites of hippocampal neurons and were isolated in a complex from mouse brain neurons. Phosphorylation was required for their interaction, for syndecan-2 to cluster, and for normal dendritic spine formation in transfected neurons. The authors propose that phosphorylation triggers clustering of syndecan-2, and that the EphB2-syndecan-2 complex subsequently initiates the recruitment of downstream signaling molecules that control dendritic spine formation.
I.M. Ethell, F. Irie, M.S. Kalo, J.R. Couchman, E.B. Pasquale, Y. Yamaguchi, EphB/Syndecan-2 signaling in dendritic spine morphogenesis. Neuron 31, 1001-1013 (2001). [Full Text]
Citation: Dendritic Spine Formation. Sci. STKE 2001, tw354 (2001).
Science Signaling. ISSN 1937-9145 (online), 1945-0877 (print). Pre-2008: Science's STKE. ISSN 1525-8882