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Sci. STKE, 16 October 2001
Vol. 2001, Issue 104, p. pe34
[DOI: 10.1126/scisignal.1042001pe34]

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Is Dimerization Of Chemokine Receptors Functionally Relevant?

Marcus Thelen and Marco Baggiolini

Institute for Research in Biomedicine, CH-6500 Bellinzona, Switzerland

Abstract: Chemokines activate lymphocytes by initiating signaling cascades through cell surface receptors that couple to heterotrimeric GTP-binding proteins. Thelen and Bagglioni describe why the recent proposal that these receptors form heterodimers and activate the Jak kinases for transducing signals should be viewed with caution.

Corresponding author: E-mail: marcus.thelen{at}irb.unisi.ch

Citation: M. Thelen, M. Baggiolini, Is Dimerization Of Chemokine Receptors Functionally Relevant? Sci. STKE 2001, pe34 (2001).

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