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Sci. STKE, 16 October 2001
Vol. 2001, Issue 104, p. re14
[DOI: 10.1126/stke.2001.104.re14]


Bridging with GAPs: Receptor Communication Through RGS Proteins

Kirk M. Druey

Molecular Signal Transduction Section, Laboratory of Allergic Diseases, National Institute of Allergy and Infectious Diseases/NIH, Rockville, MD 20852 USA.

Abstract: The regulators of heterotrimeric guanosine triphosphate (GTP)-binding protein (G protein) signaling (RGS proteins) were named for their ability to act as GTP-activating proteins (GAPs) for G proteins and, thus, limit the signal generated by G protein-coupled receptors (GPCRs). In addition to this characteristic biochemical trait, RGS proteins constitute a large family of structurally diverse proteins with variable sequence motifs that permit additional specific interactions. RGS proteins may also serve as a bridge from GPCRs to receptor tyrosine kinases or transmembrane channels, allowing signals from GPCRs to regulate signaling through other types of receptors, and vice versa.

Contact information: Tel.: 301-435-8875, Fax: 301-402-7271, E-mail: kdruey{at}

Citation: K. M. Druey, Bridging with GAPs: Receptor Communication Through RGS Proteins. Sci. STKE 2001, re14 (2001).

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