Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.

Subscribe

Sci. STKE, 23 October 2001
Vol. 2001, Issue 105, p. pe36
[DOI: 10.1126/stke.2001.105.pe36]

PERSPECTIVES

Insulin Signaling: Lessons from the Drosophila Tuberous Sclerosis Complex, a Tumor Suppressor

Jacques Montagne, Thomas Radimerski, and George Thomas

Friedrich Miescher Institute for Biomedical Research, Maulbeerstrasse 66 Basel, CH-4058, Switzerland

Abstract: The genes that encode the proteins composing the tuberous sclerosis complex (TSC) are tumor suppressors. Experiments in the model organism Drosophila melanogaster have provided insight into the identity of these genes and their functions in regulating cell size and proliferation. Montagne et al. describe the various genetic interactions that show TSC to be a regulator of the insulin signaling pathway and a regulator of progression through the cell cycle, which explains its effects on cell size and tissue and tumor growth.

Corresponding author: Telephone: 41-61-697-3012; Fax: 41-61-697-6681, e-mail: gthomas{at}fmi.ch

Citation: J. Montagne, T. Radimerski, G. Thomas, Insulin Signaling: Lessons from the Drosophila Tuberous Sclerosis Complex, a Tumor Suppressor. Sci. STKE 2001, pe36 (2001).

Read the Full Text


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Lipid metabolism in Drosophila: development and disease.
Z. Liu and X. Huang (2013)
Acta Biochim Biophys Sin 45, 44-50
   Abstract »    Full Text »    PDF »

To Advertise     Find Products


Science Signaling. ISSN 1937-9145 (online), 1945-0877 (print). Pre-2008: Science's STKE. ISSN 1525-8882