Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.


Sci. STKE, 23 October 2001
Vol. 2001, Issue 105, p. tw393
[DOI: 10.1126/stke.2001.105.tw393]

EDITORS' CHOICE

Organogenesis Blood Vessels Originating Organs

Blood not only sustains and oxygenates organs--two reports show how blood vessel endothelium plays important roles in organ development. Lammert et al. found that the endothelium supplies signals that are necessary for pancreatic differentiation and insulin expression. Removal of the dorsal aorta in Xenopus embryos led to a failure in insulin expression, whereas vascularization in transgenic mice in the posterior foregut led to ectopic islet formation and insulin expression. Matsumoto et al. used flk-1 mutant mice, an embryo tissue explant system, and an angiogenesis inhibitor to show that endothelial cells promote liver development before vascular blood flow. Bahary and Zon provide a Perspective.

E. Lammert, O. Cleaver, D. Melton, Induction of pancreatic differentiation by signals from blood vessels. Science 294, 564-567 (2001). [Abstract] [Full Text]

K. Matsumoto, H. Yoshitomi, J. Rossant, K. S. Zaret, Liver organogenesis promoted by endothelial cells prior to vascular function. Science 294, 559-563 (2001). [Abstract] [Full Text]

N. Bahary, L. I. Zon, Endothelium--Chicken soup for the endoderm. Science 294, 530-531 (2001). [Full Text]

Citation: Blood Vessels Originating Organs. Sci. STKE 2001, tw393 (2001).


To Advertise     Find Products


Science Signaling. ISSN 1937-9145 (online), 1945-0877 (print). Pre-2008: Science's STKE. ISSN 1525-8882